Abstract
Genotype–phenotype associations are fundamental to biomedical research, providing insights into hereditary diseases, developmental biology, and the function of organoids. The medaka fish (Oryzias latipes) is a powerful model organism due to its natural genetic diversity and tolerance to inbreeding. The Medaka Inbred Kiyosu–Karlsruhe (MIKK) panel, comprising 80 fully sequenced...
Viral macrodomains are an important pathogenicity factor during infection with coronaviruses, including SARS-CoV-2. These proteins are ADP-ribosyl hydrolases that bind and remove ADP-ribosylation, a post-translational modification that is associated with the innate immune response against viral infection. The non-structural protein 3 (nsP3) of SARS-CoV-2 includes such a macrodomain, known as...
Keywords: carbon ions radiation therapy, beam range verification, PET, radioactive ion beams
Charged particle therapy is a well-established and effective clinical practice, given the advantages in the dose deposition during the treatment when compared with conventional X-rays radiotherapy. On the other hand, a major drawback is the range uncertainty in dose delivery, which jeopardizes the...
The integration of morphological and molecular data is central to modern biodiversity and evolutionary research. However, current workflows often compromise one data source in favor of the other: standard DNA extraction protocols dissolve internal soft tissues, precluding post-extraction imaging and digital preservation, while the impact of high-dose radiation micro-computed tomography (µCT)...
X-ray crystallography is a cornerstone technique in providing essential information in the process of structure-based drug development. The instrument HiPhaX at PETRA III is dedicated to ‘High-throughput Pharmaceutical X-ray screening’ in an early stage of drug development aiming at a high degree of automatization. It offers a temperature- and humidity-controlled sample chamber for serial and...
