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5th Science Workshop of the Program MML

Oct 20 – 22, 2025
Karlsruhe Institute of Technology
Europe/Berlin timezone

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Session

Parallel: Life (RT3)

Oct 21, 2025, 10:30 AM
Johann-Gottfried-Tulla-Hörsaal (Karlsruhe Institute of Technology)

Johann-Gottfried-Tulla-Hörsaal

Karlsruhe Institute of Technology

Englerstraße 11, 76131 Karlsruhe

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  1. 47. Nanoscale imaging of biological samples by table-top EUV and Soft X-ray microscopy
    Sophia Kaleta
    10/21/25, 10:30 AM
  2. 48. 3D brain tissue imaging using Compton microscopy
    Margarita Zakharova (DESY, CFEL)
    10/21/25, 10:45 AM
  3. 49. Novel sample delivery for small nanoparticles and biomolecules for x-ray diffractive imaging and cryo-electron microscopy
    Madeline Memovich (DESY/CFEL)
    10/21/25, 11:00 AM
  4. 50. Room-temperature X-ray fragment screening with serial crystallography
    Sven Falke (Deutsches Elektronen-Synchrotron DESY)
    10/21/25, 11:15 AM
  5. 51. Photolyase: The Molecular Mechanism of DNA Repair
    Esther Lange
    10/21/25, 11:30 AM
  6. 52. Drug development against Mac1 from SARS-CoV-2 through crystallographic fragment screening
    Frank Lennartz (Helmholtz-Zentrum Berlin)
    10/21/25, 11:45 AM
  7. 53. First online image-guided treatment of a murine tumor with radioactive ion beams
    Tamara Vitacchio
    10/21/25, 1:00 PM
  8. 54. From cells to tissues: cryo-FIB serial lift-out X-ray tomography
    James McNally
    10/21/25, 1:15 PM
  9. 55. Proton radiobiology and therapy on eyes
    Georgios Kourkafas (HZB)
    10/21/25, 1:30 PM
  10. 56. Towards Serial Computed Tomography of Small Organisms
    Tomas Farago (KIT)
    10/21/25, 1:45 PM
  11. 57. An AI-Supported Large Scale Morphological Study: The Medaka Inbred Kiyosu-Karlsruhe Repository
    Xiaoying Tan (KIT-IPS)
    10/21/25, 2:00 PM
  12. 58. Integrating Synchrotron X-ray Imaging and DNA Sequencing of Insects
    Cristina Vasilita (Karlsruhe Institute of Technology)
    10/21/25, 2:15 PM
  13. 107. 3D brain tissue imaging using Compton microscopy
    Margarita Zakharova (DESY, CFEL)
    RT3
    Talk

    Compton X-ray microscopy exploits inelastic X-ray scattering at 60 keV photon energies to generate quantitative electron density maps of biological samples [1], while delivering reduced radiation dose compared to conventional phase-contrast techniques. Using novel wedged multilayer Laue lenses [2] it can achieve resolution comparable to—or even surpassing—that of phase-contrast imaging. These...

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  14. 164. An AI-Supported Large Scale Morphological Study: The Medaka Inbred Kiyosu–Karlsruhe Repository
    Xiaoying Tan (Laboratory for Applications of Synchrotron Radiation, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.)
    RT3
    Talk

    Abstract

    Genotype–phenotype associations are fundamental to biomedical research, providing insights into hereditary diseases, developmental biology, and the function of organoids. The medaka fish (Oryzias latipes) is a powerful model organism due to its natural genetic diversity and tolerance to inbreeding. The Medaka Inbred Kiyosu–Karlsruhe (MIKK) panel, comprising 80 fully sequenced...

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  15. 154. Drug development against Mac1 from SARS-CoV-2 through crystallographic fragment screening
    Dr Frank Lennartz (Helmholtz-Zentrum Berlin)
    RT3
    Talk

    Viral macrodomains are an important pathogenicity factor during infection with coronaviruses, including SARS-CoV-2. These proteins are ADP-ribosyl hydrolases that bind and remove ADP-ribosylation, a post-translational modification that is associated with the innate immune response against viral infection. The non-structural protein 3 (nsP3) of SARS-CoV-2 includes such a macrodomain, known as...

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  16. 89. First online image-guided treatment of a murine tumor with radioactive ion beams
    Ms Tamara Vitacchio (GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany)
    RT3
    Talk

    Keywords: carbon ions radiation therapy, beam range verification, PET, radioactive ion beams

    Charged particle therapy is a well-established and effective clinical practice, given the advantages in the dose deposition during the treatment when compared with conventional X-rays radiotherapy. On the other hand, a major drawback is the range uncertainty in dose delivery, which jeopardizes the...

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  17. 168. From Pixels to Base Pairs: Integrating µCT Scanning and DNA Sequencing of Insects
    Cristina Vasilita (Karlsruhe Institute of Technology)
    RT3
    Talk

    The integration of morphological and molecular data is central to modern biodiversity and evolutionary research. However, current workflows often compromise one data source in favor of the other: standard DNA extraction protocols dissolve internal soft tissues, precluding post-extraction imaging and digital preservation, while the impact of high-dose radiation micro-computed tomography (µCT)...

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  18. 196. Gas phase SAXS of protein complexes using our MS SPIDOC platform
    Thomas Kierspel
    RT3
    Talk

    MS SPIDOC is a novel sample delivery system for X-ray diffractive imaging at synchrotrons and X-ray Free-Electron Lasers. It accommodates biological samples ranging from small proteins to megadalton-scale particles. Using nano-electrospray ionization, ionic samples can be m/z-filtered and structurally separated prior to imaging. Here, we report the first SAXS data collected at the P12 EMBL...

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  19. 119. Novel sample delivery for small nanoparticles and biomolecules for x-ray diffractive imaging and cry-electron microscopy
    Madeline Memovich (DESY/CFEL)
    RT3
    Talk

    Cryo-electron microscopy (Cryo-EM) is one of the key techniques in the field of structural biology. Recent years brought considerable improvements both on the software and hardware of the microscopes, and resolving high-resolution structures of proteins has become a standard procedure. However, most cryo-EM grids are still prepared by plunge freezing, a technique developed about ~40 years ago....

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  20. 208. Proton radiobiology and therapy on eyes
    Georgios Kourkafas (HZB)
    RT3
    Talk

    The HZB cyclotron continues to provide protons for eye tumor treatment in collaboration with the Charité – Universitätsmedizin Berlin after 27 years and more than 5000 patients so far. Despite this established success, ongoing research aims to further improve the therapeutic outcome. In-vivo experiments with ultra-high dose rate irradiation (Flash) have exhibited enhanced preservation of the...

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  21. 175. Room-temperature X-ray fragment screening with serial crystallography
    Sven Falke (Deutsches Elektronen-Synchrotron DESY)
    RT3
    Talk

    X-ray crystallography is a cornerstone technique in providing essential information in the process of structure-based drug development. The instrument HiPhaX at PETRA III is dedicated to ‘High-throughput Pharmaceutical X-ray screening’ in an early stage of drug development aiming at a high degree of automatization. It offers a temperature- and humidity-controlled sample chamber for serial and...

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  22. 138. Towards Serial Computed Tomography of Small Organisms
    Tomas Farago (KIT)
    RT3
    Talk

    Synchrotron-based X-ray microtomography has become an indispensable technique for non-invasive morphological analysis of small organisms. Extending its application to large-scale studies—such as genotype–phenotype correlation or the comprehensive digitization of museum collections—requires a paradigm shift in methodology. To meet this demand, we introduce an integrated, highly automated...

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